ANI shows the analgesic effect of metoprolol

In 1952, Dr. Cecil Gray redefined the concept of anesthesia emphasizing the importance of the Autonomic Nervous System changing analgesia for areflexia. Opioid-free anesthesia is based on controlling the ANS response. In this case, we can see how ANI can direct OFA, making it easy for physicians to detect nociception and improve it after. When the doctor stimulates the patient by cutting with electrocautery, the HR and BP remain normal, and BIS shows no awareness. When a metoprolol bolus is given, the ANI value increases reflecting the effect of the drug and making the doctor treat the patient more precisely. The ANI technology has changed the paradigm in pain management making the patient’s outcomes better and their recovery faster.